The accident involved a Toyota Camry and a stationary tricycle.
The speeding car, with registration number LSR 724 FW, lost a tyre and rammed into a man washing his tricycle.
The vehicle then somersaulted into a ditch.
Director General, Lagos State Emergency Management Agency (LASEMA), Olufemi Oke-Osanyintolu, told NAN that the accident occurred at 5 p.m.
He confirmed that all the three adult male occupants in the car and the tricycle rider lost their lives.
Emergency responders and police officers from Odo-Noforija Divisional Headquarters evacuated the corpses to Epe General Hospital.